Mismatch repair protein expression in gastric carcinoma patients

Gastric cancer is one of the most aggressive malignancies. Although there has been a slight increase in overall survival due to inclusion targeted medications standard chemotherapeutic treatment paradigm, prognosis remains poor. New evidence suggests that certain molecular and histopathologic tumor characteristics, as well staging, may also influence patients’ prognosis. Indeed, two detailed genomic classifications gastric have recently developed by The Cancer Genome Atlas (TCGA) Asian Research Group (ACRG), showing microsatellite instability (MSI) distinct subgroup related Interestingly, MSI-H was identified separate entity GC both these are relevant cancer. Microsatellite caused frequently deficiency mismatch repair proterin (MMR) (including MLH1, MSH2, PMS2, MSH6) can be defined immunohistochemistry (IHC). offers good prognostic marker associated with different types. Therefore, identification MMR very important provide valuable information personalized Key words: cancer, instability, protein deficiency, immunohistochemistry,